IGFBP 4 Human-IGFBP

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IGFBP 4 Human

Qty


Total
$65
Catalog #
CYPS-037
Size
Description
IGFBP-4 Human Recombinant amino acids Asp22- Glu258, produced in HEK293 cells and fused with a polyhistidine tag at the C-terminus. IGFBP4 predicted Mw is 27kDa and on SDS-PAGE appears as a 32kDa band under denaturing conditions.IGFBP4 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionInsulin-like growth factor-binding protein 4 (IGFBP-4) belongs to the insulin-like growth factor binding protein (IGFBP) family. IGFBP4 includes an IGFBP domain and a thyroglobulin type-I domain. IGFBP4 binds both insulin-like growth factors (IGFs) I and II. IGFBP-4 circulates in the plasma in both glycosylated and non-glycosylated forms. IGFBPs can either inhibit or enhance the biological activities of IGF, or act in an IGF independent manner. IGFBP-4 is exceptional since it consistently inhibits several cancer cells in vivo and in vitro, sµggesting that it may function as an apoptotic factor. IGFBP4 is produced by all colon cancer cells. Binding of IGFBP-4 prolongs the half-life of the IGFs and changes their interaction with cell surface receptors.
SynonymsInsulin-like growth factor-binding protein 4, IBP-4, IGF-binding protein 4, IGFBP-4, IGFBP4, IBP4, BP-4, HT29-IGFBP.
SourceHEK293 cells.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationIGFBP 4 was lyophilized after extensive dialysis against PBS.
SolubilityIt is recommended to reconstitute the lyophilized IGFBP4 in sterile 18M-cm H2O not less than 100
StabilityLyophilized IGFBP4 althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGFBP-4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceDEAIHCPPCS
EEKLARCRPP
VGCEELVREP
GCGCCATCAL
GLGMPCGVYT
PRCGSGLRCY
PPRGVEKPLH
TLMHGQGVCM
ELAEIEAIQE
SLQPSDKDEG
DHPNNSFSPC
SAHDRRCLQK
HFAKIRDRST
SGGKMKVNGA
PREDARPVPQ
GSCQSELHRA
LERLAASQSR
THEDLYIIPI
PNCDRNGNFH
PKQCHPALDG
QRGKCWCVDR
KTGVKLPGGL
EPKGELDCHQ
LA
PurityGreater than 95.0% as determined by SDS-PAGE.
Biological ActivityThe ED50 range is 0.01-0.09
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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