IL 2 Mouse, His-Interleukin

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IL 2 Mouse, His

Qty


Total
$65
Catalog #
CYPS-631
Size
Description
Interleukin-2 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 170 amino acids (21-169 a.a) and having a molecular mass of 19.5kDa. The mouse IL-2 is fused to a 20 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionIL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which sµggests an essential role of this gene in the immune response to antigenic stimuli.
SynonymsInterleukin-2, T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2, Il2.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless clear solution.
FormulationThe Mouse IL2 protein (0.5mg/ml) is supplied in Phosphate Buffered Saline (pH7.4)0.1M NaCl, and 20% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAPTSSSTSS
STAEAQQQQQ
QQQQQQQHLE
QLLMDLQELL
SRMENYRNLK
LPRMLTFKFY
LPKQATELKD
LQCLEDELGP
LRHVLDLTQS
KSFQLEDAEN
FISNIRVTVV
KLKGSDNTFE
CQFDDESATV
VDFLRRWIAF
CQSVISTSPQ.
PurityGreater than 90.0% as determined by SDS-PAGE.
Biological ActivityMeasured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is < 2.5 ng/ml, corresponding to a specific activity of less than 400,000units/mg.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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