IL-23 Human Recombinant produced in HEK cells is a glycosylated disulfide linked homodimer, having a total molecular weight of 43kDa and 19kDa heterodimer.The IL-23 is purified by proprietary chromatographic techniques.
IL23 is composed of a subunit of the heterodimeric cytokine IL23 and the p40 subunit of interleukin 12 (IL12B). Interleukin-23 (IL-23) belongs to the IL-12 family and is produced by antigen presenting cells. IL-23 using IL12RB1 and IL-23R (specific for IL-23) can activate STAT and NF-kB pathways and stimulate the production of interferon-gamma. ). IL-23 is known to take a vital part in the inflammation process and is associated with auto immune diseases. However, unlike IL12, which acts primarily on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.
IL-23 if supplied as a sterile filtered White lyophilized (freeze-dried) powder.
IL-23 was lyophilized from a concentrated (480
It is recommended to reconstitute the lyophilized Interleukin-23 in sterile 18M-cm H2O not less than 100
Lyophilized Interleukin-23 althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-23 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Greater than 95.0% as determined by analysis by SDS-PAGE.
The activity, as determined by the dose dependent secretion of h-IFN-g from human PBMC was found to be 2 to 20ng/ml ED50.
NeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.