IL 6 Mouse-Interleukin

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IL 6 Mouse

Qty


Total
$65
Catalog #
CYPS-357
Size
Description
Interleukin-6 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 187 amino acids and having a molecular mass of 21709 Dalton. The IL-6 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionInterleukin-6 is a potent pro-inflammatory cytokine primarily produced by activated T cells and an assortment of other cells including endothelial cells and macrophages. IL-6 affects B and T lymphocytes and has been shown to have a role in host defense, acute phase reactions, immune responses and hematopoiesis.
SynonymsIFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2, IL-6, Interleukin HP-1, B-cell hybridoma growth factor.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationLyophilized from a 0.2
SolubilityIt is recommended to reconstitute the lyophilized Mouse Il-6 in sterile 18M?-cm H2O not less than 100
StabilityLyophilized Interleukin-6 althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL6 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceFPTSQVRRGD
FTEDTTPNRP
VYTTSQVGGL
ITHVLWEIVE
MRKELCNGNS
DCMNNDDALA
ENNLKLPEIQ
RNDGCYQTGY
NQEICLLKIS
SGLLEYHSYL
EYMKNNLKDN
KKDKARVLQR
DTETLIHIFN
QEVKDLHKIV
LPTPISNALL
TDKLESQKEW
LRTKTIQFIL
KSLEEFLKVT
LRSTRQT.
PurityGreater than 96.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Biological ActivityThe ED50 as determined by the dose-dependant stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is < 0.02 ng/ml, corresponding to a specific activity of > 50,000,000 units/mg.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
ReferencesTitle:Interleukin-10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice.Publication:Published online before print March 30, 2010, doi: 10.1096/fj.09-148155 Aµgust 2010 The FASEB Journal vol. 24 no. 8 2869-2880 .Link:http://www.fasebj.org/content/24/8/2869.full
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MSDS
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