JNK2a-1 Human-Jun N-terminal Kinase

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JNK2a-1 Human

Qty


Total
$65
Catalog #
PKPS-227
Size
Description
JNK2 is a soluble 48 kDa protein that is activated in response to cellular stress, radiation and growth factors. JNK2 binds to the amino terminal activation domains of c-jun or ATF2 regulating AP-1 transcriptional activity.This protein is the full-length form of the protein with a C-terminal His-tag (His-tag on COOH terminus).
Additional Information
IntroductionJUN N-terminal Kinase 2is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thoµght to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart sµggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
SynonymsMitogen-activated protein kinase 9, EC 2.7.11.24, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, JNK-55, JNK2, JNK2A, JNK2B, PRKM9, JNK2BETA, p54aSAPK, JNK2ALPHA, MAPK9, JUN N-terminal Kinase 2 alpha 1, JNK2a-1.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered clear solution.
Formulation25mM HEPES at pH 8.0, 150mM NaCl, 2mM DTT and 10% glycerol.
Amino Acid SequenceMSDSKCDSQF
YSVQVADSTF
TVLKRYQQLK
PIGSGAQGIV
CAAFDTVLGI
NVAVKKLSRP
FQNQTHAKRAYRELVLLKCV
NHKNIISLLN
VFTPQKTLEE
FQDVYLVMEL
MDANLCQVIH
MELDHERMSY
LLYQMLCGIKHLHSAGIIHR
DLKPSNIVVK
SDCTLKILDF
GLARTACTNF
MMTPYVVTRY
YRAPEVILGM
GYKENVDIWSVGCIMGELVK
GCVIFQGTDH
IDQWN
PurityGreater than 85% as determined by SDS-PAGE. Mass spectrometry of tryptic digest products for identity determination.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
StorageStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Background

N/A

Protocol

N/A

MSDS
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