Ketohexokinase Human-Protein Kinases

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Ketohexokinase Human

Qty


Total
$65
Catalog #
PKPS-366
Size
Description
Ketohexokinase Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids and having a molecular mass of 32.7 kDa.
Additional Information
IntroductionKetohexokinase catalyzes the phosphorylation of fructose to produce fructose-1-phosphate, resulting in the utilization of ATP and creation of AMP. Ketohexokinase commences initial step in the metabolism of dietary fructose and is a significant regulator of hepatic glucose metabolism. Ketohexokinase is found in liver, renal cortex, and small intestine. Its deficiency causes the benign hereditary metabolic disorder essential fructosuria, leading to fructose being excreted in the urine. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. ketohexokinase plays an unknown physiologic function that remains intact in essential fructosuria. Ketohexokinase expression is reduceed in human clear cell type of renal cell carcinoma.
SynonymsKHK, Hepatic Fructokinase, Ketohexokinase, Fructokinase.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe protein solution contains 1xPBS, pH 7.4 and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMEEKQILCVG
LVVLDVISLV
DKYPKEDSEI
RCLSQRWQRG
GNASNSCTIL
SLLGAPCAFM
GSMAPGHVAD
FVLDDLRRYS
VDLRYTVFQT
TGSVPIATVI
INEASGSRTI
LYYDRSLPDV
SATDFEKVDL
TQFKWIHIEG
RNASEQVKML
QRIDAHNTRQ
PPEQKIRVSV
EVEKPREELF
QLFGYGDVVF
VSKDVAKHLG
FQSAEEALRG
LYGRVRKGAV
LVCAWAEEGA
DA
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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