LDHA Human-Dehydrogenase

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LDHA Human

Qty


Total
$65
Catalog #
ENPS-498
Size
Description
LDHA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 352 amino acids (1-332 a.a.) and having a molecular mass of 38.8 kDa. The LDHA is fused to a 20 amino acid his tag at N-terminus and purified by conventional chromatography.
Additional Information
IntroductionLDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA is localized primarily in muscle tissue and is part of the lactate dehydrogenase family. Mutations in LDHA have been linked to exertional myoglobinuria. LDH1 is decreased in essential thrombocythemia. LDHA is induced throµgh a non-genomic pathway of estrogen action. Reduction in LDH-A activity results in stimulation of mitochondrial respiration and decrease of mitochondrial membrane potential.
SynonymsLDH-A, GSD11, LDH1, LDHM, PIG19, EC 1.1.1.27, lactate dehydrogenase M, LDH-M, LDH-1, L-lactate dehydrogenase A chain, LDH muscle subunit, Renal carcinoma antigen NY-REN-59, Cell proliferation-inducing gene 19 protein, LDHA.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe LDHA protein solution contains 20mM Tris-HCl pH-8, 100mM NaCl and 20% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MATLKDQLIY
NLLKEEQTPQ
NKITVVGVGA
VGMACAISIL
MKDLADELAL
VDVIEDKLKG
EMMDLQHGSL
FLRTPKIVSG
KDYNVTANSK
LVIITAGARQ
QEGESRLNLV
QRNVNIFKFI
IPNVVKYSPN
CKLLIVSNPV
DILTYVAWKI
SGFPKNRVIG
SGCNLDSARF
RYLMGERLGV
HPLSCHGWVL
GEHGDSSVPV
WSGMNVAGVS
LK
PurityGreater than 95.0% as determined by SDS-PAGE.
Biological ActivitySpecific activity is > 20 units/mg. in which one unit will convert 1.0 umole of pyruvate to L-lactate and beta-NAD per minute at pH 7.5 at 37°C.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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