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| Introduction | Left-Right Determination Factor 1 (LEFTY1) belongs to the TGF-beta family of proteins. LEFTY1 is required for left-right axis determination as a regulator of LEFTY2 and NODAL. An analogous secreted protein in mouse has a role in left-right asymmetry determination of organ systems during development. The LEFTY1 gene is closely linked to both a related family member and a related pseudogene. |
| Synonyms | Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B, LEFTY1, LEFTB, LEFTYB. |
| Source | HEK. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | The LEFTY1 was lyophilized from 1mg/ml in 1xPBS. |
| Solubility | It is recommended to reconstitute the lyophilized LEFTY1 in sterile water not less than 100 |
| Stability | Lyophilized LEFTY1 althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution LEFTY1 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity | Greater than 90% as obsereved by SDS-PAGE. |
| Biological Activity | The specific activity was determined by dose dependent ability to inhibit BMP-4 (6.5 ng/mL) induction of alkaline phosphatase production in the MC-3T3-E1 cell line (Mouse chondrogenic cell line) and is typically 10-40ng/ml. |
| Usage | NeoScientifics products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
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