Leptin Binding Domain Human Recombinant also called Leptin soluble receptor produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 208 amino acids and having a molecular mass of 24.5 kDa. Leptin Receptor consists of the cytokine binding domain of leptin receptor amino acids 428-635 of human leptin receptor.The Leptin Binding Domain is purified by proprietary chromatographic techniques.
OB Protein, Obesity Protein, OBS, Obesity factor, Leptin Receptor.
Sterile Filtered White lyophilized (freeze-dried) powder.
The protein was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3.
The lyophilized Leptin Binding Domain is very soluble in water and most aqueous buffers below and above the isoelectric point.
Lyophilized Leptin Binding Domain althoµgh stable at room temperature, should be stored desiccated below 0°C. Reconstituted Leptin is best stored refrigerated at 4°C.Please prevent freeze-thaw cycles.
Amino Acid Sequence
The sequence of the first four N-terminal amino acids was determined and was found to be Ala-Thr-Pro-ValBiological ActivityBiological Activity is evidenced by high affinity binding of mammalian leptins at 1:1 molar ratio.
Greater than 98.0% as determined by:(a) Analysis by SEC-HPLC.(b) Analysis by SDS-PAGE.
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