LGALS3 Human, His-Galectin

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LGALS3 Human, His

Qty


Total
$65
Catalog #
CYPS-700
Size
Description
LGALS3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 270 amino acids (1-250 a.a.) and having a molecular mass of 28.3 kDa.The LGALS3 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionGalectin-3 mediates with the alpha-3, beta-1 integrin the stimulation by cspg4 of endothelial cells migration. Galectin-3 plays an necessary part during the acquisition of vasculogenic mimicry and angiogenic properties associated with melanoma progression. LGALS3 overexpression is highly expressed in early stages of papillary carcinoma, and its expression intensity declines during tumor progression. Serum levels of LGALS3 are high in patients with thyroid malignancy but there is considerable overlap in serum LGALS3 concentrations between those with benign and malignant nodular thyroid disease. LGLAS3 takes part as an immune regulator to inhibit T-cell immune responses and promote tumor growth, as a result providing a new mechanism for tumor immune tolerance.
SynonymsGalectin-3, GAL3, MAC2, CBP35, GALB, GALIG, LGALS2, LGALS3, Galactose-specific lectin 3, Mac-2 antigen, IgE-binding protein, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Laminin-binding protein, Lectin L-29, L-31, Galactoside-binding protein, G
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe Galectin-3 His tag protein solution contains 20mM Tris-HCl pH-8, 10% glycerol & 1mM DTT.
StabilityLGALS3 althoµgh stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MADNFSLHDA
LSGSGNPNPQ
GWPGAWGNQP
AGAGGYPGAS
YPGAYPGQAP
PGAYPGQAPP
GAYPGAPGAY
PGAPAPGVYP
GPPSGPGAYP
SSGQPSATGA
YPATGPYGAP
AGPLIVPYNL
PLPGGVVPRM
LITILGTVKP
NANRIALDFQ
RGNDVAFHFN
PRFNENNRRV
IVCNTKLDNN
WGREERQSVF
PFESGKPFKI
QVLVEPDHFK
VA
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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