MAPT Human-Microtubule-Associated Protein

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MAPT Human

Qty


Total
$65
Catalog #
PRPS-302
Size
Description
MAPT Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 372 amino acids (1-352 a.a.) and having a molecular mass of 38.9 kDa (Real molecular weight on SDS-PAGE will be shift up). The MAPT is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionMAPT is a neuronal microtubule associated protein localized mostly on axons. MAPT promotes tubulin polymerisation and stabilizes microtubules, however it also serves to connect certain signalling pathways to the cytoskeleton. MAPT, in its hyperphosphorylated form, is the main part of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer''s disease (AD) brain.
SynonymsTAU, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe MAPT solution (0.5mg/ml) contains 20mM Tris-HCl pH-8, 1mM DTT, 0.2M NaCl & 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAEPRQEFEV
MEDHAGTYGL
GDRKDQGGYT
MHQDQEGDTD
AGLKAEEAGI
GDTPSLEDEA
AGHVTQARMV
SKSKDGTGSD
DKKAKGADGK
TKIATPRGAA
PPGQKGQANA
TRIPAKTPPA
PKTPPSSGEP
PKSGDRSGYS
SPGSPGTPGS
RSRTPSLPTP
PTREPKKVAV
VRTPPKSPSS
AKSRLQTAPV
PMPDLKNVKS
KIGSTENLKH
QP
PurityGreater than 85.0% as determined by SDS-PAGE.
UsageNeoScientific''s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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