MLF1 Human-Other

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MLF1 Human

Qty


Total
$65
Catalog #
PRPS-107
Size
Description
MLF1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 288 amino acids (1-268 a.a.) and having a molecular mass of 32.8kDa (Molecular weight on SDS-PAGE will appear higher). The MLF1 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionMyeloid leukemia factor 1 (MLF1) is a member of the MLF family, and is a widely expressed negative regulator of cell cycle progression functioning upstream of the tumor suppressor p53. MLF1 hinders the erythropoietin-induced erythroid terminal differentiation by averting cells from exiting the cell cycle throµgh suppression of CDKN1B/p27Kip1 levels. MLF1 generally functions in multi-potent progenitor cells, and its dysregulation may be to some extent responsible for leukemogenesis. Translocations between the MLF1 gene and nucleophosmin are linked to myelodysplastic syndrome and acute myeloid leukemia.
SynonymsMyeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe MLF1 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 5mM DTT and 200mM NaCl.
StabilityMLF1 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MFRMLNSSFE
DDPFFSESIL
AHRENMRQMI
RSFSEPFGRD
LLSISDGRGR
AHNRRGHNDG
EDSLTHTDVS
SFQTMDQMVS
NMRNYMQKLE
RNFGQLSVDP
NGHSFCSSSV
MTYSKIGDEP
PKVFQASTQT
RRAPGGIKET
RKAMRDSDSG
LEKMAIGHHI
HDRAHVIKKS
KNKKTGDEEV
NQEFINMNES
DAHAFDEEWQ
SEVLKYKPGR
HN
PurityGreater than 85.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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