MYL2 Human-Myosin Light Chain

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MYL2 Human

Qty


Total
$65
Catalog #
PRPS-531
Size
Description
MYL2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 186 amino acids (1-166) and having a molecular mass of 20.9 kDa. MYL2 is fused to a 20 amino acid His Tag fused at N-terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionMYL2 regulatory light chain is associated with cardiac myosin beta (or slow) heavy chain. Ca+ activates the phosphorylation of regulatory light chain that in turn activates contraction. Mutations in this MYL2 gene are related with mid-left ventricular chamber type hypertrophic cardiomyopathy. MYL2 is an essential protein that plays a role in the regulation of myosin ATPase activity in smooth muscle. MYL2 phosphorylation is regulated by ROCK and MLC kinase and is involved in platelet biogenesis by controlling proplatelet formation and fragmentation.
SynonymsMLC2, CMH10, MYL-2, Myosin regulatory light chain 2, MYOSIN LIGHT CHAIN REGULATORY VENTRICULAR, DKFZp779C0562, MYL2, MLC-2v, MLC-2.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationMYL2 solution containing 20mM Tris pH-8 pH-7.4, 20% glycerol and 5mM CaCl2.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAPKKAKKRA
GGANSNVFSM
FEQTQIQEFK
EAFTIMDQNR
DGFIDKNDLR
DTFAALGRVN
VKNEEIDEMI
KEAPGPINFT
VFLTMFGEKL
KGADPEETIL
NAFKVFDPEG
KGVLKADYVR
EMLTTQAERF
SKEEVDQMFA
AFPPDVTGNL
DYKNLVHIIT
HGEEKD.
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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