PA2G4 Human-Other

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PA2G4 Human

Qty


Total
$65
Catalog #
PRPS-789
Size
Description
PA2G4 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 402 amino acids (1-394 a.a.) and having a molecular mass of 44.8kDa.PA2G4 is fused to 8 amino acids His Tag at C-terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionPA2G4 belongs to the peptidase M24C family and functions as an RNA-binding protein involved in cellular proliferation and differentiation processes. PA2G4 is a component of pre-ribosomal ribonucleoprotein complexes, participating in ribosome assembly and regulating the later steps of rRNA processing. Also, PA2G4 interacts with ErbB-3 and may function as a modulator of the ErbB-3 mediated signal transduction pathway by regulating the effects of Neuregulin-1. Furthermore, PA2G4 is a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes throµgh its interactions with histone deacetylases. PA2G4 is implicated in growth inhibition and the induction of differentiation of human cancer cells. In addition, PA2G4 mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). PA2G4 associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA.
SynonymsProliferation-associated protein 2G4, Cell cycle protein p38-2G4 homolog, hG4-1, ErbB3-binding protein 1, PA2G4, EBP1, p38-2G4.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe PA2G4 protein solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMSGEDEQQEQ
TIAEDLVVTK
YKMGGDIANR
VLRSLVEASS
SGVSVLSLCE
KGDAMIMEET
GKIFKKEKEM
KKGIAFPTSI
SVNNCVCHFSPLKSDQDYIL
KEGDLVKIDL
GVHVDGFIAN
VAHTFVVDVA
QGTQVTGRKA
DVIKAAHLCA
EAALRLVKPG
NQNTQVTEAW
NKVAHSFNCT
PIEGMLSHQL
KQHVIDGEKT
IIQNPTDQQK
KDHEKAEFEV
HEVYAVDVLV
SSG
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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