PEBP1 Human-Other

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PEBP1 Human

Qty


Total
$65
Catalog #
PRPS-729
Size
Description
PEBP1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 187 amino acids (1-187 a.a.) and having a molecular mass of 21kDa.The PEBP1 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionPEBP1 (Phosphatidylethanolamine binding protein 1) belongs to the phosphatidylethanolamine-binding protein family and a serine protease inhibitor that inhibits thrombin, neuropsin. PEBP1 plays a key modulatory part in several protein kinase signaling cascades. PKC phosphorylates PEBP1, resulting in the release of Raf-1 and activation of MEK and ERK. PEBP1 is expressed in many tissues and implicated in the regulation of such physiological processes as membrane biosynthesis, spermatogenesis, neural development, and metastasis suppression.PEBP1 binds ATP, opioids and phosphatidylethanolamine, however it has lower affinity for phosphatidylinositol and phosphatidylcholine. PEBP1 may also be involved in the function of the presynaptic cholinergic neurons of the CNS. PEBP1 increases the production of choline acetyltransferase althoµgh not acetylcholinesterase. Furtheremore, PEBP1 functions in potentially sequestering toxic compounds, including locostatin which may have harmful effects on cells.Loss of PEBP1 expression may have a significant role as prognostic marker in Gastrointestinal stromal tumors. In addition, PEBP1 is found differentially expressed in the Wernicke's Area from schizophrenia patients. PEBP1 is also, an invasion suppressor protein in nasopharyngeal carcinoma.
SynonymsPhosphatidylethanolamine-binding protein 1, Prostatic-binding protein, HCNPpp, Neuropolypeptide h3, Raf kinase inhibitor protein, PEBP-1, RKIP, PEBP1, PBP, PEBP, HCNP.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe PEBP1 protein solution contains 20mM Tris-HCl buffer (pH8.0), 1mM DTT and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMPVDLSKWSG
PLSLQEVDEQ
PQHPLHVTYA
GAAVDELGKV
LTPTQVKNRP
TSISWDGLDS
GKLYTLVLTD
PDAPSRKDPK
YREWHHFLVV
NMKGNDISSG
TVLSDYVGSG
PPKGTGLHRY
VWLVYEQDRP
LKCDEPILSN
RSGDHRGKFK
VASFRKKYEL
RAPVAGTCYQ
AEWDDYVPKL
YEQLSGK.
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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