Recombinant Single Chain Cardiac Troponin I-C 2nd generation produced in E.Coli is a single, non-glycosylated, polypeptide chain (aa28-110-Linker-cTnC), having a molecular weight of 30kDa.1mg of scIC2 is equivalent to 0.82mg of full length human cardiac TNI on a molar basis.The scIC2 is purified by proprietary chromatographic techniques.
Troponin Complex is a heteromeric protein playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, Troponin I, Troponin T and TroponinC. Each subunit is responsible for part of Troponin Complex function. E.g. Troponin I inhibits ATP-ase activity of acto-myosin.Troponin T and Troponin Iare presented in cardiac muscles in different forms than in skeletal muscles. Purified subunits of rcTnI, rcTnC and rcTnT are recomplexed in vitro under appropriate conditions.
Troponin I cardiac muscle, Cardiac troponin I, TNNI3, TNNC1, CMH7, RCM1, cTnI, CMD2A, MGC116817, Troponin C slow skeletal and cardiac muscles, TN-C, TNNC1, TNNC, TNC, CMD1Z.
Sterile Filtered colourless liquid formualtion.
The protein solution contains 20mM Tris-HCl, 250mM NaCl and 50% glycerol, pH 7.5.
scIC2 althoµgh stable at 10°C for 7 days, should be stored below -18°C. Please prevent freeze-thaw cycles.
Greater than 91.0% as determined by SDS-PAGE.
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