SERPINE1 Human-Serpin

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SERPINE1 Human

Qty


Total
$65
Catalog #
ENPS-364
Size
Description
SERPINE1 Human Recombinant fused to N-terminal His-Tag produced in E.Coli is a single, non-glycosylated polypeptide chain containing 400 amino acids (24-402) and having a molecular mass of 45 kDa.The SERPINE1 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionPlasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator(tPA) and urokinase(uPA), the activators of plasminogenand hence fibrinolysis(the physiological breakdown of blood clots). It is a serine protease inhibitor(serpin) protein (SERPINE1). The other PAI, plasminogen activator inhibitor-2(PAI-2) is secreted by the placentaand only present in significant amounts during pregnancy. In addition, protease nexinacts as an inhibitor of tPA and urokinase. SERPINE1, however, is the main inhibitor of the plasminogen activators.
SynonymsPAI-1, PAI1, PLANH1, SERPINE1, PAIE, PLASMINOGEN ACTIVATOR INHIBITOR, BETA-MIGRATING ENDOTHELIAL-CELL-DERIVED TYPE.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered clear colorless solution.
Formulation150mM Na2HPO4, pH 6.6, 0.5mM NaCl, 2mM Glutathione and 0.01% Tween-80.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MVHHPPSYVA
HLASDFGVRV
FQQVAQASKD
RNVVFSPYGVASVLAMLQLT
TGGETQQQIQ
AAMGFKIDDK
GMAPALRHLY
KELMGPWNKD
EISTTDAIFVQRDLKLVQGF
MPHFFRLFRS
TVKQVDFSEV
ERARFIINDW
VKTHTKGMIS
NLLGKGAVDQLTRLVLVNAL
YFNGQWKTPF
PDSSTHRRLF
HKSDGSTVSV
PMMAQTNKFN
YTEFT
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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