TDO2 Human-Oxygenase

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TDO2 Human

Qty


Total
$65
Catalog #
ENPS-088
Size
Description
TDO2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 426 amino acids (1-406 a.a.) and having a molecular mass of 50kDa. The TDO2 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionTDO2 is a ferrous heme enzyme that catalyzes the first and rate-limiting step in the kynurenine pathway which is the major pathway of tryptophan metabolism. TDO2 integrates oxygen into the indole moiety of tryptophan. TDO2 has broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin.
SynonymsTryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase, TDO2, TPH2.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe TDO2 solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT, 1mM EDTA and 30% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MSGCPFLGNN
FGYTFKKLPV
EGSEEDKSQT
GVNRASKGGL
IYGNYLHLEK
VLNAQELQSE
TKGNKIHDEH
LFIITHQAYE
LWFKQILWEL
DSVREIFQNG
HVRDERNMLK
VVSRMHRVSV
ILKLLVQQFS
ILETMTALDF
NDFREYLSPA
SGFQSLQFRL
LENKIGVLQN
MRVPYNRRHY
RDNFKGEENE
LLLKSEQEKT
LLELVEAWLE
RT
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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