TK2 Human-Protein Kinases

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TK2 Human

Qty


Total
$65
Catalog #
PKPS-048
Size
Description
TK2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 257 amino acids (34-265 a.a) and having a molecular mass of 30.2kDa.TK2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionThymidine kinase 2 mitochondrial (TK2) is a member of the DCK/DGK family. TK2 is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase. Thymidine kinase is found in most living cells. Thymidine kinase is present in 2 forms in mammalian cells, TK1 and TK2. Thymidine kinases have a central function in the synthesis of DNA and thus in cell division, since they are part of the exceptional reaction chain to introduce deoxythymidine into the DNA. TK2 is a deoxyribonucleoside kinase which specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. TK2 localizes to the mitochondria and is essential for mitochondrial DNA synthesis. TK2 gene defects are a cause of mitochondrial DNA depletion syndrome type 2 (MTDPS2).
SynonymsThymidine kinase 2 mitochondrial, Mt-TK, TK2, MTTK, MTDPS2.
SourceE.coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationTK2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer, pH8.0, 30% glycerol, 2mM DTT and 200mM NaCl.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSHMVQRRA
WPPDKEQEKE
KKSVICVEGN
IASGKTTCLE
FFSNATDVEV
LTEPVSKWRN
VRGHNPLGLM
YHDASRWGLT
LQTYVQLTML
DRHTRPQVSS
VRLMERSIHS
ARYIFVENLY
RSGKMPEVDY
VVLSEWFDWI
LRNMDVSVDL
IVYLRTNPET
CYQRLKKRCR
EEEKVIPLEY
LEAIHHLHEE
WLIKGSLFPM
AAPVLVIEAD
HH
PurityGreater than 85% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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