Tumor Necrosis Factor -b His Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 171 amino acids fragment (35-205) and having a molecular mass of 23.3kDa with an amino-terminal hexahistidine tag. The TNF-b His is purified by standard chromatographic techniques.
TNF-? is a potent multifunctional cytokine produced mainly by activated T and B lymphocytes. The protein has been shown to have a specific potent cytotoxic activity on tumor cells and a variety of other target cells as well as being a mediator of inflammation and immune function.