TNFR2 Mouse-Tumor Necrosis Factor

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TNFR2 Mouse

Qty


Total
$65
Catalog #
CYPS-777
Size
Description
TNFR2 Mouse Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 184 amino acids and having a molecular mass of 20kDa.The TNFR2 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionTNFR2 belongs to the TNF-receptor superfamily. TNFR2 is receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. TNFR2 mediates the majority of the metabolic effects of TNF-alpha. In addition, knockout studies in mice propose a role for TNFR2 in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2 expression might have a significant role in the angiogenesis, tumor cell proliferation and metastasis of Invasive micropapillary carcinoma of the breast.There are 2 types of soluble TNF receptors: sTNFR-I and sTNFR-II, which act to neutralize the biological activities of TNF alpha and TNF beta. The levels of these soluble receptors seem to increase as a result of shedding of the extracellular domains of the membrane bound receptors. High levels of soluble TNF receptors are found in the amniotic fluid of pregnant women. TNFR2 and TNFR1 form a heterocomplex which mediates the recruitment of 2 anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. IAPs’ function in TNF-receptor signaling is unknown; nevertheless, c-IAP1 is believed to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Oxidative stress promotes TNFR1 and TNFR2 self-interaction, ligand-independent and enhanced ligand-dependent TNF signaling. TNF-a, TNFR1 and TNFR2 have roles in cellular differentiation. TNFR1 and TNFR2 function in cell type-specific renal injury.
SynonymsTumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, TNF-R2, Tumor necrosis factor receptor type II, TNF-RII, TNFR-II, p75, p80 TNF-alpha receptor, CD120b, Tnfrsf1b, Tnfr-2, Tnfr2, TNFBR, TNFR80, TNFRII, TNF-R75, TNF-R-I
SourceEscherichia Coli.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationTNFR2 protein was lyophilized from a 0.2
SolubilityIt is recommended to reconstitute the lyophilized TNFR2 in sterile 18M-cm H2O not less than 100
StabilityLyophilized TNFR2 althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution TNFR2 should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Amino Acid SequenceMPAQVAFTPY
APEPGSTCRL
REYYDQTAQM
CCSKCSPGQH
AKVFCTKTSD
TVCDSCEDST
YTQLWNWVPE
CLSCGSRCSS
DQVETQACTR
EQNRICTCRP
GWYCALSKQE
GCRLCAPLRK
CRPGFGVARP
GTETSDVVCK
PCAPGTFSNT
TSSTDICRPH
QICNVVAIPG
NASMDAVCTS
TSPT.
PurityGreater than 97.0% as determined by SDS-PAGE.
Biological ActivityThe ED50 as determined by its ability to inhibit the TNF-? mediated cytotoxicity in the L-929 cells is less than 0.2
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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