ICAM1-Monoclonal Antibodies

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ICAM1

Qty


Total
$300
Catalog #
A0307
Antibody Type
Monoclonal Antibody
Gene ID
3383
Swiss Prot
P13597
Size
Species
Mouse
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB IF
Recommended DilutionWB 1:500 - 1:1000 IF 1:20 - 1:50
Calculated MW59kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human ICAM1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymCD54; Icam-1; Ly-47; MALA-2; MGC6195; Icam1;
Images
  • A0307: image 1

    Western blot analysis of extracts of mouse brain cell line, using ICAM1 antibody.

Background

Intercellular cell adhesion molecule-1 (CD54 or ICAM-1) is a cell surface glycoprotein that belongs to the immunoglobulin superfamily (IgSF) of adhesion molecules. CD54 is expressed at low levels in diverse cell types, and is induced by cytokines (TNF-α, interleukin-1) and bacterial lipopolysaccharide (1). Apical localization of CD54 on endothelial cells (or basolateral localization on epithelial cells) is a prerequisite for leukocyte trafficking through the endothelial (or epithelial) barrier (1). Apical expression of CD54 on epithelial cells mediates pathogen invasion as well as host defense, a pattern also observed in tumors (1). CD54 also functions as a co-stimulator on antigen presenting cells, binding to its receptor LFA-1 (leukocyte function-associated antigen-1) on the surface of T cells during antigen presentation (2). Cross-linking of CD54 or binding to its ligand triggers activation of Src family kinases and the Rho/ROCK pathway (3-7). Phosphorylation on Tyr485 of CD54 is required for its association with SHP-2 (5). SHP-2 seems essential for CD54-induced Src activation (7).

Protocol

N/A

MSDS
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