NEUROD1-Methylated Antibodies

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NEUROD1

Qty


Total
$220
Catalog #
A1147
Antibody Type
Polyclonal Antibody
Gene ID
4760
Swiss Prot
Q13562
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Calculated MW40kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human NEUROD1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationk
SynonymNEUROD1;BETA2;BHF-1;NEUROD;bHLHa3 ;
Images
  • A1147: image 1

    Western blot analysis of T47D cell and pancreas cell lysate using NEUROD1 antibody.

Background

a member of the basic helix-loop-helix (bHLH) family of transcription factors. These proteins function by forming heterodimers with E-proteins and binding to the canonical E-box sequence CANNTG (1,2). Neuronal activity results in CaMKII-mediated phosphorylation of NeuroD at Ser336, which is necessary for formation and growth of dendrites (3,4). NeuroD is also phosphorylated at Ser274 though the results are context dependent as phosphorylation by Erk stimulates NeuroD activity in pancreatic β-cells while phosphorylation by GSK-3β inhibits NeuroD in neurons (3). NeuroD is crucially important in both the pancreas and developing nervous system, and plays a large role in the development of the inner ear and mammalian retina (3). Mice lacking NeuroD become severely diabetic and die shortly after birth due to defects in β-cell differentiation (2,3,5,6). The lack of NeuroD in the brain results in severe defects in development (5). Human mutations have been linked to a number of types of diabetes including type I diabetes mellitus and maturity-onset diabetes of the young (1,3).

Protocol

N/A

MSDS
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