RAC2-Methylated Antibodies

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RAC2

Qty


Total
$220
Catalog #
A1139
Antibody Type
Polyclonal Antibody
Gene ID
5880
Swiss Prot
P15153
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Calculated MW21kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human RAC2
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationq
SynonymRAC2;EN-7;Gx;HSPC022 ;
Images
  • A1139: image 1

    Western blot analysis of extracts of H560 cells, using RAC2 antibody.

  • A1139: image 2

    Immunohistochemistry of paraffin-embedded rat brain using RAC2 antibody at dilution of 1:100 (40x lens).

  • A1139: image 3

    Immunohistochemistry of paraffin-embedded human esophagus using RAC2 antibody at dilution of 1:100 (40x lens).

  • A1139: image 4

    Immunohistochemistry of paraffin-embedded mouse stomach using RAC2 antibody at dilution of 1:100 (40x lens).

  • A1139: image 5

    Immunohistochemistry of paraffin-embedded rat lung using RAC2 antibody at dilution of 1:100 (40x lens).

  • A1139: image 6

    Immunohistochemistry of paraffin-embedded human esophagus using RAC2 antibody at dilution of 1:100 (40x lens).

  • A1139: image 7

    Immunohistochemistry of paraffin-embedded mouse stomach using RAC2 antibody at dilution of 1:100 (40x lens).

Background

Rac and Cdc42 are members of the Rho-GTPase family. In mammals, Rac exists as three isoforms, Rac1, Rac2 and Rac3, which are highly similar in sequence. Rac1 and Cdc42, the most widely studied of this group, are ubiquitously expressed. Rac2 is expressed in cells of hematopoietic origin, and Rac3, while highly expressed in brain, is also found in many other tissues. Rac and Cdc42 play key signaling roles in cytoskeletal reorganization, membrane trafficking, transcriptional regulation, cell growth and development (1). GTP binding stimulates the activity of Rac/Cdc42, and the hydrolysis of GTP to GDP through the protein's intrinsic GTPase activity, rendering it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs). Another level of regulation is achieved through the binding of RhoGDI, a guanine nucleotide dissociation inhibitor, which retains Rho family GTPases, including Rac and Cdc42, in their inactive GDP-bound state (2,3).

Protocol

N/A

MSDS
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