DHH Human-Hedgehog Protein

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DHH Human

Qty


Total
$65
Catalog #
CYPS-474
Size
Description
DHH Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 197 amino acids (23-198) and having a molecular mass of 22 kDa. DHH is fused to His-tag (20 a.a.) at N-terminus and is purified by proprietary chromatographic techniques.
Additional Information
IntroductionDHH is part of the Hedgehog family which encodes signaling molecules that are involved in regulating morphogenesis. DHH protein is a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. Additionally, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throµghout the organism. Defects in DHH protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. DHH plays a role both male gonadal differentiation and perineurial development.DHH plays a role in intercellular signaling which is essential for a variety of patterning events during development. DHH functions as a spermatocyte survival factor in the testes & is essential for testes development.
SynonymsHHG-3, Desert Hedgehog homolog, MGC35145, Desert hedgehog protein, DHH.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationDHH solution containing 20mM MES pH-5.5, 0.5mM DTT and 20% glycerol.
StabilityDHH Human Recombinant althoµgh stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MCGPGRGPVG
RRRYARKQLV
PLLYKQFVPG
VPERTLGASG
PAEGRVARGS
ERFRDLVPNY
NPDIIFKDEE
NSGADRLMTE
RCKERVNALA
IAVMNMWPGV
RLRVTEGWDE
DGHHAQDSLH
YEGRALDITT
SDRDRNKYGL
LARLAVEAGF
DWVYYESRNH
VHVSVKADNS
LAVRAGG.
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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