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Home / PRODUCTS / Catalog Antibodies / Monoclonal Antibodies
- SPECIFICATION
- BACKGROUND
- DOCUMENTS
- REVIEW
ADDITIONAL INFORMATION
SYNONYMS
GKAF; ZNF259
REACTIVITY
Human,Mouse
TESTED APPLICATIONS
ELISA,WB,IHC-P
RECOMMENDED DILUTION
WB,1:500 - 1:1000|IHC-P,1:50 - 1:200
CALCULATED MW
51kDa
OBSERVED MW
51kDa
IMMUNOGEN
A synthetic peptide corresponding to a sequence within amino acids 360-459 of human ZNF259 (O75312).
POSITIVE SAMPLES
Mouse brain
CELLULAR LOCALIZATION
Cajal body,Cell projection,Cytoplasm,Nucleus,axon,gem,growth cone,nucleolus,perinuclear region,
STORAGE BUFFER
Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
BACKGROUND
The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene.
REVIEW
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