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Datasheet MSDS

DNMT1 Rabbit pAb

Quantity
Quantity
$108.00
  • Catalog # A15050
  • Host species Rabbit
  • Gene ID 1786
  • Purification Affinity purification
  • Swiss Prot P26358
  • Isotype IgG
  • SPECIFICATION
  • BACKGROUND
  • DOCUMENTS
  • REVIEW

ADDITIONAL INFORMATION

SYNONYMS

AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI; DNMT1

REACTIVITY

Human,Mouse,Rat

TESTED APPLICATIONS

ELISA,WB,IHC-P,IF/ICC,IP

RECOMMENDED DILUTION

WB,1:500 - 1:1000|IHC-P,1:50 - 1:200|IF/ICC,1:50 - 1:200|IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells

CALCULATED MW

183kDa

OBSERVED MW

200kDa

IMMUNOGEN

Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of DNMT1 (NP_001370.1).

POSITIVE SAMPLES

HeLa,293T,Jurkat,U-87MG,Mouse testis

CELLULAR LOCALIZATION

Nucleus,

STORAGE BUFFER

Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.

BACKGROUND

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

DOCUMENTS

Datasheet

MSDS

REVIEW

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