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Home / PRODUCTS / Catalog Antibodies / Monoclonal Antibodies
- SPECIFICATION
- BACKGROUND
- DOCUMENTS
- REVIEW
ADDITIONAL INFORMATION
SYNONYMS
CBTF; DRBF; MMP4; MPP4; NF90; NFAR; NF110; NF90a; NF90b; NF90c; NFAR2; TCP80; DRBP76; NF110b; NFAR-1; NFAR-2; NFAR90; TCP110; MPP4110; NF90ctv; NFAR110; MPHOSPH4; NF-AT-90; ILF3
REACTIVITY
Human,Mouse,Rat
TESTED APPLICATIONS
ELISA,WB,IHC-P
RECOMMENDED DILUTION
WB,1:1000 - 1:5000|IHC-P,1:50 - 1:200
CALCULATED MW
95kDa
OBSERVED MW
90kDa/100kDa
IMMUNOGEN
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ILF3 (Q12906).
POSITIVE SAMPLES
HeLa,Raji,C6,SH-SY5Y,Mouse testis
CELLULAR LOCALIZATION
Cytoplasm,Nucleus,Nucleolus,
STORAGE BUFFER
Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
BACKGROUND
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
REVIEW
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