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Datasheet MSDS

CDK8 Rabbit mAb

Quantity
Quantity
$148.00
  • Catalog # A9654
  • Host species Rabbit
  • Gene ID 1024
  • Purification Affinity purification
  • Swiss Prot P49336
  • Isotype IgG
  • SPECIFICATION
  • BACKGROUND
  • DOCUMENTS
  • REVIEW

ADDITIONAL INFORMATION

SYNONYMS

K35; IDDHBA; CDK8

REACTIVITY

Mouse,Rat

TESTED APPLICATIONS

ELISA,WB

RECOMMENDED DILUTION

WB,1:500 - 1:1000

CALCULATED MW

53kDa

OBSERVED MW

55kDa

IMMUNOGEN

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CDK8 (P49336).

POSITIVE SAMPLES

Mouse brain,Rat liver,Rat brain

CELLULAR LOCALIZATION

Nucleus

STORAGE BUFFER

Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

BACKGROUND

This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

DOCUMENTS

Datasheet

MSDS

REVIEW

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