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- SPECIFICATION
- BACKGROUND
- DOCUMENTS
- REVIEW
ADDITIONAL INFORMATION
SYNONYMS
ATS; ASLN; ATS1; CA54; COL4A5
REACTIVITY
Human
TESTED APPLICATIONS
ELISA,WB,IF/ICC
RECOMMENDED DILUTION
WB,1:500 - 1:2000|IF/ICC,1:500 - 1:1000
CALCULATED MW
161kDa
OBSERVED MW
161kDa
IMMUNOGEN
Recombinant fusion protein containing a sequence corresponding to amino acids 1462-1691 of human COL4A5 (NP_203699.1).
POSITIVE SAMPLES
22Rv1,NCI-H460,HepG2
CELLULAR LOCALIZATION
Secreted,basement membrane,extracellular matrix,extracellular space,
STORAGE BUFFER
Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
BACKGROUND
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene.
REVIEW
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