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Reactivity | Human Mouse Rat |
Tested applications | WB IHC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
Calculated MW | 55kDa |
Observed MW | Refer to Figures |
Immunogen | Recombinant protein of human ACVR1C |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | b |
Synonym | ACVR1C;ACVRLK7;ALK7 ; |
Western blot analysis of 293T cell lysate using ACVR1C antibody.
Immunohistochemistry of paraffin-embedded rat brain using ACVR1C antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using ACVR1C antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse lung using ACVR1C antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse brain using ACVR1C antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse kidney using ACVR1C antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse stomach using ACVR1C antibody at dilution of 1:100 (40x lens).
ACTR-IC (Activin receptor type 1C), also referred to as Activin receptor-like kinase 7 (ALK-7), is a type I serine/threonine kinase receptor. ACTA-IC contains an extracellular binding domain, an intracellular serine/threonine kinase domain preceded by a GS box and a transmembrane domain. It is expressed throughout the digestive and central nervous system and localizes to the cell surface. Four ACTR-IC transcripts are generated by alternative splicing. Transcript 1 is the functional full length receptor, transcript 2 lacks a complete receptor binding domain and transcripts 3 and 4 are soluble proteins that lack a transmembrane domain. ACTR-IC is a receptor for Activin AB, Activin B and Nodal. In pancreatic cells, ACTR-IC forms a complex with Activin receptor type IIB (ACTR-IIB). The kinase domain of ACTR-IC can induce Smad2 and Smad3 signalling pathways. In some cell lines, ACTR-IC overexpression induces apoptosis and inhibits proliferation.
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