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+1-888.733.6849
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| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Calculated MW | 57kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human ACVR2A |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | ACVR2; ACTRII; |
Western blot analysis of extracts of mouse brain, using ACVR2A antibody.
Immunohistochemistry of paraffin-embedded mouse kidney using ACVR2A antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human lung using ACVR2A antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human colon using ACVR2A antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human colon carcinoma using ACVR2A antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human esophageal cancer using ACVR2A antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human stomach using ACVR2A antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human gastric cancer using ACVR2A antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded mouse brain using ACVR2A antibody at dilution of 1:100 (x40 lens).
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
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