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Reactivity | Human Mouse Rat |
Tested applications | WB IHC ICC IP FC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 ICC 1:50 - 1:200 IP 1:20 - 1:50 FC 1:10 - 1:50 |
Calculated MW | 57 kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human ALPL |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | HOPS; TNAP; APTNAP; TNSALP; AP-TNAP; |
Immunohistochemistry of paraffin-embedded mouse kidney using ALPL antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver using ALPL antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver cancer using ALPL antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human kidney using ALPL antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse intestin using ALPL antibody at dilution of 1:100 (40x lens).
Immunofluorescence
This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.
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