APP-Monoclonal Antibodies

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APP

Qty


Total
$220
Catalog #
A11445
Antibody Type
Polyclonal Antibody
Gene ID
351
Swiss Prot
P05067
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:100
Calculated MW87kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human APP
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymAPP;AAA;ABETA;ABPP;AD1;APPI;CTFgamma;CVAP;PN2;amyloidP; Amyloid beta A4 protein; A4; Beta Amyloid
Images
  • A11445: image 1

    Immunohistochemistry of paraffin-embedded human stomach using APP antibody at dilution of 1:100 (40x lens).

  • A11445: image 2

    Immunohistochemistry of paraffin-embedded human esophagus using APP antibody at dilution of 1:100 (40x lens).

Background

Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains the amyloid domain (Aβ), which can be released by a two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimer's disease (1). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (2-5). Phosphorylation at Thr668 (at a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell cycle-dependent and peaks during G2/M-phase (4). APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation (5,6).

Protocol

N/A

MSDS
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