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+1-617.299.7367 (Int’l)
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sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-888.733.6849
+1-617.299.7367 (Int’l)
| Reactivity | Human Mouse |
| Tested applications | IHC IF |
| Recommended Dilution | IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Calculated MW | 15kDa |
| Observed MW | Refer to figures |
| Immunogen | Recombinant protein of human ASIP |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | ASP; AGSW; AGTI; AGTIL; SHEP9; |
Immunohistochemistry of paraffin-embedded human prostate cancer using ASIP antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human gastric cancer using ASIP antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis of HeLa cell using ASIP antibody. Blue: DAPI for nuclear staining.
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
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