|Reactivity||Human Mouse Rat|
|Tested applications||WB IHC IF|
|Recommended Dilution||WB 1:500 - 1:2000
IHC 1:50 - 1:100IF 1:50 - 1:200|
|Observed MW||Refer to Figures|
|Immunogen||A synthetic peptide of human ATF6|
|Storage Buffer||Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonym||ATF6 ;ATF6A ; Processed cyclic AMP-dependent transcription factor ATF-6 alpha ; Activating transcription factor 6 alpha ;|
Western blot analysis of extracts of various cell lines, using ATF6 antibody.
Immunohistochemistry of paraffin-embedded human esophagus using ATF6 antibody.
Immunohistochemistry of paraffin-embedded rat brain using ATF6 antibody.
Immunofluorescence analysis of A549 cell using ATF6 antibody. Blue: DAPI for nuclear staining
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
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