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| Reactivity | Human |
| Tested applications | WB IHC FC |
| Recommended Dilution | WB 1:500 - 1:1000 IHC1:50 - 1:100 FC 1:20 - 1:50 |
| Calculated MW | 98kDa |
| Observed MW | Refer to Figures |
| Immunogen | A synthetic peptide of human AXL |
| Storage Buffer | Store at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | AXL;JTK11;UFO; |
Axl, Sky and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor (1). Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB (2,3). A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells (4).
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