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+1-888.733.6849
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+1-888.733.6849
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| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC ICC IF FC |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 ICC 1:50 - 1:200 IF 1:50 - 1:200 FC 1:20 - 1:50 |
| Calculated MW | 18 kDa |
| Observed MW | Refer to figures |
| Immunogen | Recombinant protein of human BBC3 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | JFY1; PUMA; JFY-1; |
Immunohistochemistry of paraffin-embedded mouse stomach using BBC3 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human mammary cancer using BBC3 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human gastric cancer using BBC3 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse intestin using BBC3 antibody at dilution of 1:100 (40x lens).
Immunofluorescence
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
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