BCL2A1-Polyclonal Antibodies

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BCL2A1

Qty


Total
$220
Catalog #
A0134
Antibody Type
Polyclonal Antibody
Gene ID
597
Swiss Prot
Q16548
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB IHC FC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:100 FC1:20 - 1:50
Calculated MW20kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human BCL2A1
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationb
SynonymGRS; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5;
Images
  • A0134: image 1

    Western blot analysis of extracts of Mouse lung, using BCL2A1 antibody.

Background

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Protocol

N/A

MSDS
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