|Reactivity||Human Mouse Rat|
|Tested applications||WB IHC|
|Recommended Dilution||WB 1:500 - 1:2000
IHC 1:50 - 1:100|
|Observed MW||Refer to Figures|
|Immunogen||Recombinant protein of human BCR|
|Storage Buffer||Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonym||ALL;BCR1;CML;D22S11;D22S662;PHL;Breakpoint cluster region protein antibody, Renal carcinoma antigen NY-REN-26 antibody;|
Western blot analysis of extracts of various cells, using BCR antibody.
Immunohistochemistry of paraffin-embedded human stomach using BCR antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human prostate using BCR antibody at dilution of 1:100 (x40 lens).
The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.
Neo Scientific welcomes feedback from its customers.
If you have used an our product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information.
If you have any additional inquiries please email technical services at [email protected]
Thank you for your support.