BCR-Polyclonal Antibodies

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BCR

Qty


Total
$220
Catalog #
A0068
Antibody Type
Polyclonal Antibody
Gene ID
613
Swiss Prot
P11274
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:100
Calculated MW130/160kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human BCR
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymALL;BCR1;CML;D22S11;D22S662;PHL;Breakpoint cluster region protein antibody, Renal carcinoma antigen NY-REN-26 antibody;
Images
  • A0068: image 1

    Western blot analysis of extracts of various cells, using BCR antibody.

  • A0068: image 2

    Immunohistochemistry of paraffin-embedded human stomach using BCR antibody at dilution of 1:100 (x40 lens).

  • A0068: image 3

    Immunohistochemistry of paraffin-embedded human prostate using BCR antibody at dilution of 1:100 (x40 lens).

Background

The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.

Protocol

N/A

MSDS
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