BLNK-Monoclonal Antibodies

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BLNK

Qty


Total
$220
Catalog #
A0638
Antibody Type
Monoclonal Antibody
Gene ID
29760
Swiss Prot
Q8WV28
Size
Species
Mouse
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:1000
Calculated MW50kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human BLNK
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonymbca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65
Images
  • A0638: image 1

    Western blot analysis of extracts of NCI-H460 cell line, using BLNK antibody.

Background

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.

Protocol

N/A

MSDS
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