For quotations, please use our online quotation form, and you may also contact us by
sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-888.733.6849
+1-617.299.7367 (Int’l)
Reactivity | Human Mouse |
Tested applications | WB IHC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Calculated MW | 42kDa |
Observed MW | Refer to Figures |
Immunogen | Recombinant protein of human BSG |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | 5F7; CD147; EMMPRIN; M6; OK; TCSF; |
Western blot analysis of extracts of mouse heart cell lines, using BSG antibody.
Immunohistochemistry of paraffin-embedded human stomach cancer using BSG antibody at dilution of 1:200 (x40 lens).
Immunohistochemistry of paraffin-embedded Human esophageal using BSG antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded Human gastric using BSG antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded Human liver injury using BSG antibody at dilution of 1:100 (x40 lens).
Basigin (EMMPRIN, CD147) is a type I integral membrane receptor protein belonging to the immunoglobulin superfamily (1). Basigin is a glycosylated protein with four known isoforms, of which isoform 2 is the most abundantly expressed (2). Multiple functions have been ascribed to Basigin; foremost among these is stimulating the secretion of extracellular matrix metalloproteinases by adjacent fibroblasts, a function which has been implicated in promoting tumor progression (2-4). Research studies have shown that Basigin is overexpressed by many tumor cells, and its expression level may correlate with tumor malignancy (5,6). A recent study identified the BASIGIN gene as a regulatory target of Slug, suggesting a role for Basigin in the process of epithelial-mesenchymal transition (7). Basigin has also been identified as a marker for a subset of highly suppressive regulatory T cells (8), and as an obligate receptor for the malarial parasite Plasmodium falciparum on human erythrocytes (9).
N/A