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Reactivity | Human Mouse Rat |
Tested applications | WB IHC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Calculated MW | 12kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human C8orf4 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | TC1; TC-1; |
Immunohistochemistry of paraffin-embedded rat lung using C8orf4 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using C8orf4 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse lung using C8orf4 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse brain using C8orf4 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat lung using C8orf4 antibody at dilution of 1:100 (40x lens).
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
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