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Reactivity | Human Mouse Rat |
Tested applications | WB IHC ICC IF FC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 ICC 1:50 - 1:200 IF 1:50 - 1:200 FC 1:20 - 1:50 |
Calculated MW | 48/30/12 kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human CASP2 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57; |
Immunohistochemistry of paraffin-embedded mouse kidney using CASP2 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung using CASP2 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human kidney using CASP2 antibody at dilution of 1:100 (40x lens).
Immunofluorescence
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
N/A