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+1-617.299.7367 (Int’l)
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| Reactivity | Human |
| Tested applications | WB IHC IF |
| Recommended Dilution | WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Calculated MW | 18kDa，41kDa，43kDa |
| Observed MW | Refer to Figures |
| Immunogen | A synthetic peptide of human CASP8 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | bis |
| Synonym | ALPS2B; CAP4; Casp-8; FLICE; FLJ17672; MACH; MCH5; MGC78473; Caspase8; |
Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.
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