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| Reactivity | Human Mouse |
| Tested applications | WB IF |
| Recommended Dilution | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Calculated MW | 46kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human CASP9 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | bi |
| Synonym | MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; |
Caspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family (1,2). Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf 1. Apaf-1 mediated activation of caspase-9 involves instrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response (3-6). Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis (7-10).
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