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+1-888.733.6849
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| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Calculated MW | 49kDa |
| Observed MW | Refer to figures |
| Immunogen | Recombinant protein of human CCM2 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | OSM; C7orf22; PP10187; |
Western blot analysis of extracts of various tissues, using CCM2 antibody.
Immunohistochemistry of paraffin-embedded human liver using CCM2 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded rat heart using CCM2 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded mouse heart using CCM2 antibody at dilution of 1:100 (x40 lens).
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
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