For quotations, please use our online quotation form, and you may also contact us by
sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-888.733.6849
+1-617.299.7367 (Int’l)
Reactivity | Human Mouse Rat |
Tested applications | WB IHC ICC IP |
Recommended Dilution | WB 1:100 - 1:2000 IHC 1:50 - 1:200 ICC 1:50 - 1:200 IP 1:20 - 1:50 |
Calculated MW | 34 kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human CCND1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | BCL1; PRAD1; U21B31; D11S287E; |
Immunohistochemistry of paraffin-embedded mouse liver using CCND1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human tonsil using CCND1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver cancer using CCND1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung using CCND1 antibody at dilution of 1:100 (40x lens).
Immunofluorescence
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
N/A