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Reactivity | Human Mouse |
Tested applications | WB IHC FC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:100 FC1:20 - 1:50 |
Calculated MW | 47kD |
Observed MW | Refer to Figures |
Immunogen | A synthetic peptide of human CCNE1 |
Storage Buffer | Store at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | dm |
Synonym | CCNE; Cyclin E1; |
Cyclin E1 (CCNE1) is a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. CCNE1, an essential cyclin activating Cdk2, regulates the G1-S phase transition of the mammalian cell division cycle. Its timing expression plays a direct role in the initiation of DNA replication , the control of histone biosynthesis, and the centrosome cycle. CCNE1 is associated with disease progression in various malignancies and is associated clinically with poor prognosis.
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