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Reactivity | Human |
Tested applications | WB IHC IP FC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:20 - 1:50 FC 1:20 - 1:50 |
Calculated MW | 23 kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human CD3E |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | T3E; TCRE; IMD18; |
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
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